Topikal Atorvastatinin Random Paternli Cilt Fleplerinin Yaşayabilirliğine Etkisi ,Deneysel Çalışma

Augmentation of viability random pattern flaps has long been an issue in plastic surgery. Up to date no agents were clinically introduced. Atorvastatins are used for lipid lowering. They also effective on flap survival with their angiogenic, anti-inflammatory, antioxidant effects systeic administration. In this study, Atorvastatin is topically alleviation Mc Farlane rats. Wibstar albino type 20 male rats weighing about 180-230 grams classified as experiment and control group. Results evaluated by necrosis ratios, lymphocyte cells, neutrophile capillary granulation tissue density the 7th postoperative day.. Flap areas Sasaki's paratemplate method. Tissue biopsies 1x1 cm at transition zone between necrotic healthy tissue, embedded parafin blocks after fixation 10% formalin. Biopsies sliced 4 micrometer thickness a microtome. Cross sections painted hematoxylene eosin light microscope. Whitneyy U test was performed clinical histopathological evaluation groups (p<0,05). alleviated. Average ratios 32.1% group 14.17% experimental Capillary cell found be higher atorvastatin . Granulation not significantly higher.. Atorvastatins, when applied topically, survival. Further studies should carried out human use.